SCHEMBL6629299

SCHEMBL6629299

CC[C@H]1CCCCN1C[C@@H](O)C(N)=O.O=S(=O)(O)c1cc(Cl)sc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 4/20 0.41
PKM P14618 1/20 0.38
TSHR P16473 2/20 0.38
ALDH1A1 P00352 3/20 0.37
EPHX2 P34913 1/20 0.37
TP53 P04637 2/20 0.37
TERT O14746 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ATM Q13315 1/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
PSEN1 P49768 1/20 0.34
PSEN2 P49810 1/20 0.34
APH1B Q8WW43 1/20 0.34
NCSTN Q92542 1/20 0.34
APH1A Q96BI3 1/20 0.34
PSENEN Q9NZ42 1/20 0.34
MAPT P10636 1/20 0.34
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6629304 0.87 SLC6A9 (0.46) SLC6A9PKMTSHRALDH1A1EPHX2
SCHEMBL6629302 0.78 SLC6A9 (0.63) SLC6A9TSHRALDH1A1L3MBTL1
SCHEMBL5242244 0.78 SLC6A9 (0.63) SLC6A9TSHRALDH1A1L3MBTL1
SCHEMBL5240176 0.78 MEN1 (0.41) SLC6A9TSHRALDH1A1TERTTDP1
SCHEMBL5241119 0.78 MEN1 (0.41) SLC6A9TSHRALDH1A1TERTTDP1
SCHEMBL5241519 0.75 SLC6A9 (0.40) SLC6A9TSHRALDH1A1TERTTDP1
SCHEMBL301846 0.65 PKM (0.52) SLC6A9PKMEPHX2TDP1KMT2A
SCHEMBL5137127 0.64 PKM (0.50) SLC6A9PKMEPHX2TDP1KMT2A
SCHEMBL11760745 0.64 PKM (0.50) SLC6A9PKMEPHX2TDP1KMT2A
SCHEMBL11757841 0.64 PKM (0.50) SLC6A9PKMEPHX2TDP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1455777-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM PLC (GB) 2004-09-15 EP claimed
WO-2003055478-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-10 WO claimed
EP-1455777-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM PLC (GB) 2004-09-15 EP disclosed
WO-2003055478-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-10 WO disclosed