Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | NPY2R | P49146 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577646 | 0.92 | NPC1 (0.72) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL29771385 | 0.87 | POLB (0.69) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL5681508 | 0.87 | POLB (0.69) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL30516994 | 0.87 | POLB (0.72) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL29372498 | 0.87 | POLB (0.72) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL1344307 | 0.87 | POLB (0.72) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL7084829 | 0.84 | HSD17B10 (0.67) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL11237313 | 0.84 | POLB (0.72) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL3925183 | 0.83 | PLG (0.62) | NPC1RAB9APOLBKDM4EMAPT | |
| SCHEMBL11242411 | 0.82 | NPC1 (0.65) | NPC1RAB9APOLBKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283205-B1 | NAPHTHOL DERIVATIVES | UENO SEIYAKU OYO KENKYUJO KK (JP) | 2004-09-22 | — | — | EP | disclosed |
| EP-1283205-A1 | NAPHTHOL DERIVATIVES | KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-20020151720-A1 | NAPHTHOL DERIVATIVES | KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) | 2002-10-17 | — | — | US | disclosed |
| US-6451988-B1 | AN AZO COMPOUND AND A METAL COMPLEX WHICH ARE SYNTHESIZED WITH THE NAPHTHOL DERIVATIVE | KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) | 2002-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151720-A1 | NAPHTHOL DERIVATIVES | NAP1L1, IK, NAP1L4 | NPC1 1203/4885RAB9A 3387/4885POLB 2484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.