Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 10/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.52 |
| ▸ | HTR3B | O95264 | 4/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634865 | 0.92 | CHRNA7 (0.55) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6634206 | 0.86 | HTR3A (0.58) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6629652 | 0.82 | CHRNA7 (0.59) | HTR3ACHRNA7 | |
| SCHEMBL6843826 | 0.82 | CHRNA7 (0.54) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6631171 | 0.81 | NPC1 (0.39) | CHRNA7 | |
| SCHEMBL6636698 | 0.80 | CHRNA7 (0.58) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6631603 | 0.80 | CHRNA7 (0.57) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL1459352 | 0.79 | HTR3A (0.57) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6846164 | 0.78 | CHRNA7 (0.57) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6650684 | 0.78 | CHRNA7 (0.58) | HTR3ACHRNA7HTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404674-A2 | QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-07 | — | — | EP | claimed |
| WO-2002100858-A2 | QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-19 | — | — | WO | claimed |