Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 15/20 | 0.52 |
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | MMP2 | P08253 | 10/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | MMP7 | P09237 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MMP14 | P50281 | 2/20 | 0.46 |
| ▸ | MMP15 | P51511 | 1/20 | 0.46 |
| ▸ | MMP16 | P51512 | 1/20 | 0.46 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6626541 | 0.94 | ADAM17 (0.53) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6627253 | 0.93 | ADAM17 (0.52) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6628321 | 0.92 | ADAM17 (0.52) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6626825 | 0.92 | ADAM17 (0.62) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6626798 | 0.91 | ADAM17 (0.53) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6626945 | 0.89 | ADAM17 (0.52) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6629402 | 0.83 | ADAM17 (0.51) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6631779 | 0.82 | ADAM17 (0.53) | ADAM17MMP3MMP2MMP9MMP1 | |
| Trifluoroacetic Acid SCHEMBL6628306 | 0.81 | ADAM17 (0.41) | ADAM17MMP3MMP2MMP9MMP1 | |
| SCHEMBL7425875 | 0.79 | ADAM17 (0.68) | ADAM17MMP3MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-B1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-05-26 | — | — | EP | disclosed |