Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 8/20 | 0.38 |
| ▸ | CASP1 | P29466 | 6/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629417 | 0.88 | CASP1 (0.41) | ADAM17LCKCASP1MMEACE | |
| SCHEMBL6627770 | 0.88 | CASP1 (0.41) | ADAM17LCKCASP1MMEACE | |
| SCHEMBL6628836 | 0.88 | CASP1 (0.43) | ADAM17LCKCASP1MMEACE | |
| SCHEMBL6627209 | 0.87 | CASP1 (0.42) | ADAM17LCKCASP1MMEACE | |
| SCHEMBL6628441 | 0.85 | CASP1 (0.38) | ADAM17LCKCASP1MMEACE | |
| SCHEMBL6628442 | 0.85 | CASP1 (0.38) | ADAM17LCKCASP1MMEACE | |
| SCHEMBL6628827 | 0.85 | LCK (0.45) | LCKCASP1MMEACE | |
| SCHEMBL6628832 | 0.85 | LCK (0.45) | LCKCASP1MMEACE | |
| SCHEMBL6629127 | 0.85 | RAB9A (0.46) | LCKCASP1MMEACEIL1B | |
| SCHEMBL6671983 | 0.83 | CASP1 (0.38) | ADAM17LCKCASP1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030100550-A1 | Carboxamide diazepin derivatives, preparation method, use as medicines, pharmaceutical compositions and use thereof | AVENTIS PHARMA S.A. (FR) | 2003-05-29 | — | — | US | claimed |
| EP-1246824-B1 | CARBOXAMIDE DIAZEPIN DERIVATIVES, PREPARATION METHOD, USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2004-06-09 | — | — | EP | disclosed |
| US-20030100550-A1 | Carboxamide diazepin derivatives, preparation method, use as medicines, pharmaceutical compositions and use thereof | AVENTIS PHARMA S.A. (FR) | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100550-A1 | Carboxamide diazepin derivatives, preparation method, use as medicines, pharmaceutical compositions and use thereof | HRH4, HRH3, HRH2 | ADAM17 2579/4885LCK 4642/4885CASP1 2506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.