Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.40 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | TXN | P10599 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL665148 | 0.90 | PARP1 (0.50) | DDAH1EPHX2HTTPARP1ACHE | |
| SCHEMBL664160 | 0.86 | CHRNA7 (0.43) | DDAH1EPHX2RAB9AHTTPARP1 | |
| SCHEMBL662573 | 0.82 | RAB9A (0.43) | DDAH1EPHX2NPC1RAB9AHTT | |
| SCHEMBL6755331 | 0.77 | ALDH1A1 (0.48) | DDAH1EPHX2NPC1RAB9ABCHE | |
| SCHEMBL663661 | 0.76 | PARP1 (0.45) | NPC1RAB9AHTTCYP1A2CYP2D6 | |
| SCHEMBL630228 | 0.74 | PARP1 (0.69) | PARP1 | |
| SCHEMBL11889849 | 0.74 | PARP1 (0.54) | PARP1 | |
| SCHEMBL6753927 | 0.74 | BCHE (0.46) | DDAH1EPHX2NPC1RAB9ABCHE | |
| SCHEMBL663093 | 0.74 | PARP1 (0.45) | EPHX2NPC1RAB9ABCHETRPC3 | |
| SCHEMBL665230 | 0.74 | PARP1 (0.43) | EPHX2NPC1RAB9ABCHETRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160324829-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBVIE INC. (US) | 2016-11-10 | — | — | US | disclosed |
| US-20150005354-A1 | Combination Therapy With Parp Inhibitors | ABBVIE INC. | 2015-01-01 | — | — | US | disclosed |
| US-20150005355-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBVIE INC. | 2015-01-01 | — | — | US | disclosed |
| US-20130225647-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBVIE INC. (US) | 2013-08-29 | — | — | US | disclosed |
| US-20120264795-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBVIE INC. | 2012-10-18 | — | — | US | disclosed |
| US-20120190720-A1 | Combination Therapy With Parp Inhibitors | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120045524-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2012-02-23 | — | — | US | disclosed |
| US-20110152336-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110151023-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
| US-7550603-B2 | 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors | ABBOTT LABORATORIES INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20090029966-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | disclosed |
| US-20080293795-A1 | temozolomide and veliparib for breast cancer | ABBOTT LABORATORIES | 2008-11-27 | — | — | US | disclosed |
| US-20080280867-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2008-11-13 | — | — | US | disclosed |
| US-20080146638-A1 | primary small cell lung cancer with veliparib and temozolomide; poly/adp-ribose/polymerase (PARP) | ABBOTT LABORATORIES (US) | 2008-06-19 | — | — | US | disclosed |
| US-20070265324-A1 | Combination Therapy with Parp Inhibitors | ABBOTT LABORATORIES | 2007-11-15 | — | — | US | disclosed |
| US-20060229289-A1 | 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors | ABBVIE INC. | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110151023-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 3114/4885EPHX2 3335/4885NPC1 1967/4885 |
| US-20160324829-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 2624/4885EPHX2 3533/4885NPC1 2386/4885 |
| US-20090029966-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 2624/4885EPHX2 3533/4885NPC1 2386/4885 |
| US-20150005354-A1 | Combination Therapy With Parp Inhibitors | PARP2, PARP1, PARP3 | DDAH1 3114/4885EPHX2 3335/4885NPC1 1967/4885 |
| US-20070265324-A1 | Combination Therapy with Parp Inhibitors | PARP2, PARP1, PARP3 | DDAH1 3114/4885EPHX2 3335/4885NPC1 1967/4885 |
| US-20130225647-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 3114/4885EPHX2 3335/4885NPC1 1967/4885 |
| US-20080146638-A1 | primary small cell lung cancer with veliparib and temozolomide; poly/adp-ribose/polymerase (PARP) | PARP1, PARP2, PARP3 | DDAH1 2937/4885EPHX2 4690/4885NPC1 3872/4885 |
| US-20110152336-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 3114/4885EPHX2 3335/4885NPC1 1967/4885 |
| US-20120045524-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 3114/4885EPHX2 3335/4885NPC1 1967/4885 |
| US-20060229289-A1 | 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors | PARP1, PARP2, PARP4 | DDAH1 2015/4885EPHX2 3384/4885NPC1 2152/4885 |
| US-20080293795-A1 | temozolomide and veliparib for breast cancer | PARP1, PARP2, BRCA1 | DDAH1 3236/4885EPHX2 4718/4885NPC1 2960/4885 |
| US-20080280867-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 2624/4885EPHX2 3533/4885NPC1 2386/4885 |
| US-20150005355-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP2, PARP1, PARP3 | DDAH1 2624/4885EPHX2 3533/4885NPC1 2386/4885 |
| US-20120264795-A1 | COMBINATION THERAPY WITH PARP INHIBITORS | PARP1, PARP2, PARP12 | DDAH1 2396/4885EPHX2 2792/4885NPC1 2447/4885 |
| US-20120190720-A1 | Combination Therapy With Parp Inhibitors | PARP2, PARP1, PARP3 | DDAH1 3114/4885EPHX2 3335/4885NPC1 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.