Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25121090 | 0.84 | GPR119 (0.51) | GPR119KDM4EMAPTPTPN2PTPN1 | |
| SCHEMBL4466569 | 0.83 | GPR119 (0.50) | HTTGPR119KDM4EMAPT | |
| SCHEMBL25719736 | 0.82 | GPR119 (0.51) | GPR119KDM4EMAPTPTPN2PTPN1 | |
| SCHEMBL29090674 | 0.79 | GPR119 (0.49) | GPR119KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL10324281 | 0.79 | GPR119 (0.49) | GPR119KDM4EMAPT | |
| SCHEMBL7478208 | 0.78 | GPR119 (0.65) | GPR119KDM4EMAPT | |
| SCHEMBL27822178 | 0.78 | GPR119 (0.47) | GPR119KDM4EMAPTPTPN2PTPN1 | |
| SCHEMBL1557148 | 0.78 | GPR119 (0.49) | HTTGPR119KDM4EALDH1A1MAPT | |
| SCHEMBL28646427 | 0.77 | GPR119 (0.51) | HTTGPR119KDM4EMEN1KMT2A | |
| SCHEMBL27822180 | 0.77 | GPR119 (0.48) | GPR119KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389194-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002088101-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-11-07 | — | — | WO | disclosed |