Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364049 | 0.87 | GRM8 (0.48) | MEN1CYP3A4KMT2AGRM8GRM7 | |
| SCHEMBL11136047 | 0.81 | KMT2A (0.51) | MAPTMEN1LMNAKMT2AGRM8 | |
| SCHEMBL6103933 | 0.80 | ALDH1A1 (0.50) | CTNNB1MAPTMEN1NR1I2LMNA | |
| SCHEMBL9364620 | 0.80 | LMNA (0.51) | MAPTMEN1LMNAKMT2AGRM8 | |
| SCHEMBL10443391 | 0.80 | GRM8 (0.43) | MAPTMEN1LMNACYP3A4KMT2A | |
| SCHEMBL7428731 | 0.78 | CTNNB1 (0.57) | CTNNB1MAPTMEN1NR1I2LMNA | |
| SCHEMBL31414009 | 0.78 | CTNNB1 (0.57) | CTNNB1MAPTMEN1NR1I2LMNA | |
| SCHEMBL8827742 | 0.77 | GRM8 (0.43) | MAPTMEN1LMNAKMT2AGRM8 | |
| SCHEMBL11135267 | 0.76 | KMT2A (0.48) | MAPTMEN1NR1I2LMNAKMT2A | |
| SCHEMBL4155484 | 0.76 | CTNNB1 (0.74) | CTNNB1MAPTMEN1NR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |