Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550107 | 0.84 | CCKBR (0.42) | CCKBRPAX8AKT1HRH2OPRM1 | |
| SCHEMBL1118519 | 0.80 | CCKBR (0.42) | CCKBRPAX8HRH2OPRM1HTR2B | |
| SCHEMBL28191402 | 0.80 | CCKBR (0.45) | CCKBRPAX8AKT1HRH2OPRM1 | |
| SCHEMBL5536820 | 0.80 | CCKBR (0.42) | CCKBRPAX8AKT1HRH2OPRM1 | |
| SCHEMBL12013752 | 0.80 | CCKBR (0.42) | CCKBRPAX8HRH2OPRM1HTR2B | |
| SCHEMBL3692425 | 0.80 | HTR2A (0.42) | CCKBRAKT1HRH2OPRM1HTR2B | |
| SCHEMBL12141050 | 0.80 | CCKBR (0.42) | CCKBRPAX8HRH2OPRM1HTR2B | |
| SCHEMBL11851728 | 0.77 | CCKBR (0.40) | CCKBRPAX8AKT1HRH2OPRM1 | |
| SCHEMBL5543945 | 0.77 | CCKBR (0.40) | CCKBRPAX8AKT1HRH2OPRM1 | |
| SCHEMBL22455608 | 0.77 | MEN1 (0.47) | CCKBRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037865-A4 | SYNTHESIS OF CC-1065/DUOCARMYCIN ANALOGS | SCRIPPS RESEARCH INST (US) | 2004-03-31 | — | — | EP | disclosed |
| US-20020082424-A1 | Synthesis of CC-1065/duocarmycin analogs | THE SCRIPPS RESEARCH INSTITUTE | 2002-06-27 | — | — | US | disclosed |
| US-6310209-B1 | INTERMEDIATES INVOLVED IN THE 5-EXO-TRIG RADICAL CYCLIZATION OF AN ARYL HALIDE ONTO A TETHERED VINYL CHLORIDE FORMING THE DIHYDROINDOLE C-RING WITH CHLORINE INSTALLED AS A SUITABLE LEAVING GROUP FOR SUBSEQUENT CYCLOPROPANE SPIROCYCLIZATION. | THE SCRIPPS RESEARCH INSTITUTE | 2001-10-30 | — | — | US | disclosed |
| EP-1037865-A1 | SYNTHESIS OF CC-1065/DUOCARMYCIN ANALOGS | The Scripps Research Institute (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029642-A1 | SYNTHESIS OF CC-1065/DUOCARMYCIN ANALOGS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082424-A1 | Synthesis of CC-1065/duocarmycin analogs | CBR3, C2CD5, SIRT5 | CCKBR 1270/4885PAX8 4461/4885AKT1 2471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.