Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.33 |
| ▸ | PPARG | P37231 | 10/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 9/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6062592 | 0.88 | DAGLA (0.41) | PPARAPPARGTP53TSHRPPARD | |
| SCHEMBL6629199 | 0.85 | CTSS (0.34) | PPARAPPARGTSHRPTPN1PTPN2 | |
| SCHEMBL6629193 | 0.85 | CTSS (0.34) | PPARAPPARGTSHRPTPN1PTPN2 | |
| SCHEMBL6629197 | 0.85 | CTSS (0.34) | PPARAPPARGTSHRPTPN1PTPN2 | |
| SCHEMBL6629847 | 0.82 | PTPN1 (0.38) | PPARGPTPN1PTPN2HDAC6 | |
| SCHEMBL6681717 | 0.81 | PTPN1 (0.34) | PTPN1PTPN2 | |
| SCHEMBL6063015 | 0.80 | PTPN2 (0.33) | PTPN1PTPN2HDAC6 | |
| SCHEMBL6063021 | 0.80 | PTPN2 (0.33) | PTPN1PTPN2HDAC6 | |
| SCHEMBL6063487 | 0.80 | ALDH1A1 (0.35) | PTPN1PTPN2 | |
| SCHEMBL6063485 | 0.80 | ALDH1A1 (0.35) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |