Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1071734 | 0.91 | REN (0.43) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL662365 | 0.88 | REN (0.40) | RENKCNH2HSD11B1HTR2ACYP3A4 | |
| SCHEMBL1071679 | 0.87 | REN (0.44) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1083626 | 0.85 | REN (0.39) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1083631 | 0.85 | REN (0.39) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1074074 | 0.85 | REN (0.43) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1518498 | 0.85 | REN (0.43) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1072457 | 0.84 | REN (0.45) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1074676 | 0.83 | REN (0.38) | RENSLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL663478 | 0.83 | SLC6A4 (0.41) | RENSLC6A4SLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | REN 1/4885SLC6A4 1352/4885SLC6A2 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.