Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450086 | 0.84 | TACR3 (1.00) | TACR3LMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL28806102 | 0.81 | TACR3 (0.83) | TACR3LMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL10391576 | 0.79 | TACR3 (0.76) | TACR3LMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL6447770 | 0.79 | TACR3 (0.75) | TACR3LMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL4497529 | 0.78 | NSD2 (0.57) | — | |
| SCHEMBL23722853 | 0.78 | ACACB (0.66) | TACR3LMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL28511608 | 0.77 | MAPT (0.82) | TACR3LMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL28806105 | 0.77 | TACR3 (0.76) | TACR3LMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL14970878 | 0.77 | KDM4E (0.75) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14133006 | 0.77 | TACR3 (0.72) | TACR3LMNAALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490341-A1 | NOVEL ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080579-A1 | NOVEL ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | disclosed |