Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.72 |
| ▸ | KLK7 | P49862 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | APEX1 | P27695 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29547423 | 0.87 | KMT2A (0.66) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL23722851 | 0.85 | KDM4E (0.67) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL12218347 | 0.85 | RAB9A (0.92) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL23722866 | 0.83 | KDM4E (0.67) | KDM4ESMN1; SMN2LMNAKMT2AKLK7 | |
| SCHEMBL29578969 | 0.81 | KMT2A (0.73) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL29779110 | 0.79 | USP30 (1.00) | KDM4ESMN1; SMN2KMT2AKLK7USP30 | |
| SCHEMBL18115676 | 0.79 | USP30 (1.00) | KDM4ESMN1; SMN2KMT2AKLK7USP30 | |
| SCHEMBL6456853 | 0.79 | KLK7 (0.62) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL13792873 | 0.79 | MCHR1 (0.71) | KDM4ESMN1; SMN2KMT2AKLK7RAB9A | |
| SCHEMBL6456858 | 0.79 | KLK7 (0.62) | KDM4ESMN1; SMN2ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2013074059-A2 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | CDA, DCTD, ADA | KDM4E 1984/4885SMN1; SMN2 2561/4885ALDH1A1 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.