Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.77 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630704 | 0.88 | SIRT1 (0.70) | SIRT1TDP1MAPTTSHRHSD17B10 | |
| SCHEMBL1030659 | 0.87 | SIRT1 (1.00) | SIRT1TDP1MAPTTSHRHSD17B10 | |
| SCHEMBL6627708 | 0.86 | SIRT1 (0.77) | SIRT1PARP1MAPTTSHRHSD17B10 | |
| SCHEMBL6630665 | 0.86 | SIRT1 (0.77) | SIRT1PARP1TDP1MAPTTSHR | |
| SCHEMBL23018582 | 0.84 | SIRT1 (0.55) | SIRT1TDP1MAPTL3MBTL1BCL2L1 | |
| SCHEMBL11334883 | 0.84 | SIRT1 (0.74) | SIRT1MAPTPOLBBLML3MBTL1 | |
| SCHEMBL3077375 | 0.82 | SIRT1 (0.77) | SIRT1PARP1TDP1MAPTTSHR | |
| SCHEMBL6632571 | 0.81 | SIRT1 (0.70) | SIRT1PARP1TDP1MAPTTSHR | |
| SCHEMBL6129059 | 0.81 | SIRT1 (0.50) | SIRT1PARP1TDP1MAPTTSHR | |
| SCHEMBL7695938 | 0.81 | SIRT1 (0.74) | SIRT1PARP1MAPTTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | claimed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | claimed |