Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28797668 | 0.71 | MAPK14 (0.50) | MAPK14PTGS2CASP3KDM4ENPC1 | |
| SCHEMBL27358119 | 0.68 | DPP4 (0.42) | PTGS2PDE3BPDE3AAHRCHRM2 | |
| SCHEMBL1773966 | 0.68 | TTR (0.46) | KDM4EPDE3BPDE3AAHR | |
| SCHEMBL16695304 | 0.65 | PTGS2 (0.42) | MAPK14PTGS2KDM4ENPC1TP53 | |
| SCHEMBL21087940 | 0.65 | ALDH1A1 (0.45) | AHRCHRM2CHRM1CHRM3 | |
| SCHEMBL31067066 | 0.64 | ABL1 (0.47) | MAPK14PTGS2KDM4ENPC1TP53 | |
| SCHEMBL1262207 | 0.64 | GRM2 (0.48) | MAPK14PTGS2KDM4ENPC1TP53 | |
| SCHEMBL31067069 | 0.64 | GRM2 (0.48) | MAPK14PTGS2KDM4ENPC1TP53 | |
| SCHEMBL31066929 | 0.62 | GRM2 (0.47) | MAPK14PTGS2KDM4ENPC1TP53 | |
| SCHEMBL10950612 | 0.62 | MAPK14 (0.79) | MAPK14PTGS2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425283-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003018589-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2003-03-06 | — | — | WO | disclosed |