Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.59 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952758 | 0.87 | NSD2 (0.61) | SIRT1NSD2ALDH1A1CA12CA1 | |
| SCHEMBL11334883 | 0.80 | SIRT1 (0.74) | SIRT1ALDH1A1CA12CA1CA2 | |
| SCHEMBL26676979 | 0.79 | NSD2 (0.47) | SIRT1NSD2ALDH1A1RXFP1KDM4E | |
| SCHEMBL1030659 | 0.76 | SIRT1 (1.00) | SIRT1ALDH1A1CA12CA1CA2 | |
| SCHEMBL3077375 | 0.75 | SIRT1 (0.77) | SIRT1ALDH1A1RXFP1KDM4EPOLB | |
| SCHEMBL6630671 | 0.74 | SIRT1 (0.77) | SIRT1ALDH1A1CA12CA1CA2 | |
| SCHEMBL6630665 | 0.74 | SIRT1 (0.77) | SIRT1ALDH1A1CA12CA1CA2 | |
| SCHEMBL6627708 | 0.74 | SIRT1 (0.77) | SIRT1ALDH1A1CA12CA1CA2 | |
| SCHEMBL3151758 | 0.73 | KCNQ3 (0.43) | NSD2ALDH1A1RXFP1KDM4EPOLB | |
| SCHEMBL7695938 | 0.73 | SIRT1 (0.74) | SIRT1ALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |