Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 4/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | PDE5A | O76074 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585832 | 0.82 | PDE4A (0.36) | LMNAPOLBTSHRPDE4APDE4B | |
| SCHEMBL11089172 | 0.78 | ADORA2A (0.36) | LMNATSHRPDE4APDE4BPDE4C | |
| SCHEMBL9018625 | 0.76 | ALDH1A1 (0.32) | LMNAPOLBTSHRPDE4APDE4B | |
| SCHEMBL16298438 | 0.69 | PDE5A (0.68) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL16298470 | 0.69 | PDE5A (0.64) | PDE5A | |
| SCHEMBL8133177 | 0.68 | PDE4A (0.59) | LMNATSHRPDE4APDE4BPDE4C | |
| SCHEMBL11804290 | 0.67 | TSHR (0.47) | LMNAPOLBTSHRMEN1KMT2A | |
| SCHEMBL10800120 | 0.65 | MEN1 (0.49) | LMNATSHRPDE4APDE4BPDE4C | |
| SCHEMBL10811499 | 0.61 | GDA (0.38) | — | |
| SCHEMBL11066311 | 0.59 | HTT (0.51) | LMNAPOLBTSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421084-A1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | Schering Corporation (US) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003020724-A1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |