Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.63 |
| ▸ | CCND1 | P24385 | 11/20 | 0.63 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.63 |
| ▸ | CDK2 | P24941 | 7/20 | 0.63 |
| ▸ | CAMK2B | Q13554 | 6/20 | 0.63 |
| ▸ | CAMK2G | Q13555 | 6/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 6/20 | 0.63 |
| ▸ | CAMK2A | Q9UQM7 | 6/20 | 0.63 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.63 |
| ▸ | CDK1 | P06493 | 4/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.63 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.63 |
| ▸ | CDK9 | P50750 | 1/20 | 0.63 |
| ▸ | MAP3K9 | P80192 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629885 | 0.91 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6632580 | 0.87 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL3075228 | 0.86 | MAP3K9 (0.80) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL22566990 | 0.79 | CDK4 (0.86) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL1395043 | 0.78 | CDK4 (1.00) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6627743 | 0.76 | PRKD3 (0.65) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6630190 | 0.76 | CDK4 (0.62) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7354146 | 0.76 | MAP3K9 (0.68) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL3268039 | 0.76 | MAP3K9 (0.76) | CDK4CCND1CAMK2BCAMK2GCAMK2D | |
| SCHEMBL6630441 | 0.76 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088823-B1 | Fused pyrrolocarbazoles | CEPHALON INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-0785938-B1 | FUSED PYRROLOCARBAZOLES | CEPHALON INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1088823-A1 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-5705511-A | ENZYME INHIBITORS, ANTIINFLAMMATORY, TROPHIC FACTOR, ANTICANCER CELL GROWTH | CEPHALON, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5591855-A | KINASE INHIBITORS, TROPHIC FACTOR-INDUCED ACTIVITY ENHANCEMENT, CELL SURVIVAL | CEPHALON, INC. (US) | 1997-01-07 | — | — | US | disclosed |