Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K9 | P80192 | 5/20 | 0.80 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.80 |
| ▸ | MAP3K10 | Q02779 | 4/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.80 |
| ▸ | PRKCG | P05129 | 4/20 | 0.80 |
| ▸ | PRKCB | P05771 | 4/20 | 0.80 |
| ▸ | PRKCA | P17252 | 4/20 | 0.80 |
| ▸ | PRKCH | P24723 | 4/20 | 0.80 |
| ▸ | PRKCI | P41743 | 4/20 | 0.80 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.80 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.80 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.80 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.80 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.80 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.80 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 2/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.63 |
| ▸ | CDK4 | P11802 | 4/20 | 0.62 |
| ▸ | CCND1 | P24385 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354146 | 0.90 | MAP3K9 (0.68) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL6627743 | 0.87 | PRKD3 (0.65) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL6630190 | 0.87 | CDK4 (0.62) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL6629885 | 0.86 | CDK4 (0.63) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL6630441 | 0.86 | CDK4 (0.63) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL6631769 | 0.86 | CDK4 (0.63) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL6632580 | 0.86 | CDK4 (0.63) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL3082217 | 0.82 | MAP3K9 (1.00) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL3072275 | 0.82 | MAP3K11 (1.00) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG | |
| SCHEMBL12219429 | 0.82 | MAP3K9 (0.66) | MAP3K9MAP3K11MAP3K10PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410267-B2 | Regioselective reduction of fused pyrrolocarbazoles-5,7-diones | TEVA SANTE (FR) | 2013-04-02 | — | — | US | disclosed |
| US-20110224436-A1 | REGIOSELECTIVE REDUCTION OF FUSED PYRROLOCARBAZOLES-5,7-DIONES | CEPHALON FRANCE (FR) | 2011-09-15 | — | — | US | disclosed |
| US-7789610-B2 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-1126855-B1 | USE OF FUSED PYRROLOCARBAZOLES FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON INC (US) | 2007-05-09 | — | — | EP | disclosed |
| EP-1088823-B1 | Fused pyrrolocarbazoles | CEPHALON INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1126855-A4 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON INC (US) | 2004-05-19 | — | — | EP | disclosed |
| US-6448283-B1 | FUSED PYRROLOCARBAZOLES; HEARING LOSS AND LOSS OF THE SENSE OF BALANCE | CEPHALON, INC. | 2002-09-10 | — | — | US | disclosed |
| US-20020115706-A1 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. | 2002-08-22 | — | — | US | disclosed |
| EP-0785938-B1 | FUSED PYRROLOCARBAZOLES | CEPHALON INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1126855-A1 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-1088823-A1 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-2000018407-A1 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON, INC. (US) | 2000-04-06 | — | — | WO | disclosed |
| EP-0785938-A1 | FUSED PYRROLOCARBAZOLES | CEPHALON, INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5594009-A | KINASE INHIBITORS, TROPHIC FACTOR-INDUCED ACTIVITY ENHANCEMENT, CELL SURVIVAL | CEPHALON, INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5591855-A | KINASE INHIBITORS, TROPHIC FACTOR-INDUCED ACTIVITY ENHANCEMENT, CELL SURVIVAL | CEPHALON, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5475110-A | Treating nervous system disorders and inflammation, inhibiting protein and tyrosine kinases, inhibiting cell growth | CEPHALON, INC. (US) | 1995-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020115706-A1 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | GJB2, GAP43, MYOC | MAP3K9 2839/4885MAP3K11 2895/4885MAP3K10 2520/4885 |
| US-20110224436-A1 | REGIOSELECTIVE REDUCTION OF FUSED PYRROLOCARBAZOLES-5,7-DIONES | CYP51A1, DHPS, PRMT7 | MAP3K9 2177/4885MAP3K11 1596/4885MAP3K10 2902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.