Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K9 | P80192 | 9/20 | 0.76 |
| ▸ | MAP3K11 | Q16584 | 9/20 | 0.76 |
| ▸ | PRKCA | P17252 | 5/20 | 0.76 |
| ▸ | KDR | P35968 | 4/20 | 0.76 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.76 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.76 |
| ▸ | MAP3K10 | Q02779 | 3/20 | 0.76 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.76 |
| ▸ | PRKCG | P05129 | 3/20 | 0.76 |
| ▸ | PRKCB | P05771 | 3/20 | 0.76 |
| ▸ | PRKCH | P24723 | 3/20 | 0.76 |
| ▸ | PRKCI | P41743 | 3/20 | 0.76 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.76 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.76 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.76 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.76 |
| ▸ | PARP1 | P09874 | 4/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629443 | 0.87 | MAP3K9 (0.76) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL3072275 | 0.87 | MAP3K11 (1.00) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL3268623 | 0.85 | MAP3K9 (0.73) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL6629885 | 0.85 | CDK4 (0.63) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL14494184 | 0.85 | MAP3K9 (0.72) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL14494154 | 0.85 | KDR (0.74) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL14494163 | 0.83 | MAP3K9 (0.69) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL14494166 | 0.81 | KDR (0.69) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL14510328 | 0.81 | KDR (0.67) | MAP3K9MAP3K11PRKCAKDRPRKCQ | |
| SCHEMBL14494156 | 0.81 | KDR (0.79) | MAP3K9MAP3K11PRKCAKDRPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383813-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2013-02-26 | — | — | US | disclosed |
| US-20120004253-A1 | Novel Fused Pyrrolocarbazoles | CEPHALON, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-8044064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-8044064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20100152196-A1 | Novel Fused Pyrrolocarbazoles | CEPHALON, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| US-20100152196-A1 | Novel Fused Pyrrolocarbazoles | CEPHALON, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| US-7671064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-7169802-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169802-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2007-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152196-A1 | Novel Fused Pyrrolocarbazoles | PC, PYCR1, CYP11B2 | MAP3K9 3651/4885MAP3K11 3535/4885PRKCA 2189/4885 |
| US-20120004253-A1 | Novel Fused Pyrrolocarbazoles | PC, PYCR1, CYP11B2 | MAP3K9 3651/4885MAP3K11 3535/4885PRKCA 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.