Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663308 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAALDH1A1DRD4USP5 | |
| SCHEMBL10186181 | 0.83 | DGAT1 (0.47) | SMN1; SMN2ALDH1A1DRD4USP5 | |
| SCHEMBL664303 | 0.73 | CCR1 (0.47) | SMN1; SMN2ALDH1A1USP5IDO1KDM4E | |
| SCHEMBL10185472 | 0.73 | HPGD (0.51) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL9072652 | 0.71 | HPGD (0.54) | SMN1; SMN2LMNAALDH1A1DRD4PPARD | |
| SCHEMBL10184835 | 0.71 | HPGD (0.44) | SMN1; SMN2LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL10184275 | 0.70 | HPGD (0.54) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL22102107 | 0.70 | DGAT1 (0.42) | ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL662783 | 0.69 | DGAT1 (0.46) | SMN1; SMN2LMNAKDM4EHPGDPOLB | |
| SCHEMBL662784 | 0.69 | DGAT1 (0.46) | SMN1; SMN2LMNAKDM4EHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423182-A1 | DIACYLETHYLENEDIAMINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | SMN1; SMN2 4464/4885LMNA 2889/4885ALDH1A1 963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.