Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.79 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | SMPD1 | P17405 | 6/20 | 0.65 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828433 | 0.95 | CYP3A4 (0.77) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL9158846 | 0.94 | CYP3A4 (0.74) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL8828336 | 0.91 | CYP3A4 (0.84) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL18239557 | 0.91 | CYP3A4 (0.90) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL7430428 | 0.89 | CYP1A2 (1.00) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| Hydrochloric Acid SCHEMBL7194533 | 0.87 | BLM (1.00) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| Hydrochloric Acid SCHEMBL29651387 | 0.87 | BLM (1.00) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL13969525 | 0.86 | CYP3A4 (0.81) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL7266640 | 0.85 | CYP3A4 (0.79) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL11546332 | 0.85 | CYP3A4 (0.79) | CYP3A4CYP1A2CYP2D6BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040266772-A1 | Polymorph salt of a pryridazinone derivative for the treatment of arrythmia | EGIS GYOGYSZERGYAR RT. (HU) | 2004-12-30 | — | — | US | disclosed |
| EP-1417179-A1 | POLYMORPH SALT OF A PYRIDAZINONE DERIVATIVE FOR THE TREATMENT OF ARRHYTHMIA | Egis Gyogyszergyar Rt. (HU) | 2004-05-12 | — | — | EP | disclosed |
| US-6570037-B2 | Reacting a primary amine derivative containing another secondary or tertiary amine with a nitrobenzene containing carbonyl halide group | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 2003-05-27 | — | — | US | disclosed |
| CN-1109033-C | 8-substituted-9H-1,3-dioxolo/4,5-h/2,3/benzodiazepine derivatives, as Ampa/kainate receptor inhibitors | EGIS PHARMACEUTICAL R RT (HU) | 2003-05-21 | — | — | CN | disclosed |
| WO-2003010150-A1 | POLYMORPH SALT OF A PYRIDAZINONE DERIVATIVE FOR THE TREATMENT OF ARRYTHMIA | EGIS Gyógyszergyár Rt. (HU) | 2003-02-06 | — | — | WO | disclosed |
| US-20020107243-A1 | Nitro-benzamides useful as Anti-arrhythmic agents | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES | 2002-08-08 | — | — | US | disclosed |
| US-20010025054-A1 | Nitro-benzamides useful as anti-arrhythmic agents | SMITHKLINE BEECHAM P.L.C. | 2001-09-27 | — | — | US | disclosed |
| CN-1272846-A | 8-substituted-9H-1, 3-dioxolane/4, 5-H/2, 3/benzodiazepine * derivatives as Ampa/kainic acid receptor inhibitors | EGIS PHARMACEUTICAL R RT (HU) | 2000-11-08 | — | — | CN | disclosed |
| EP-0788474-B1 | NITRO-BENZAMIDES USEFUL AS ANTI-ARRHYTHMIC AGENTS | SMITHKLINE BEECHAM (FR) | 2000-05-03 | — | — | EP | disclosed |
| US-5977179-A | Nitro-benzamides useful as anti-arrhythmic agents | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5292770-A | Butenoic acid derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5166188-A | Cardiovascular disorders, antiischemic agents | EISAI CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5047417-A | Butenoic or propenoic acid derivatives | EISAI CO. LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |
| US-4134980-A | Phenylalkylamino-alkyl derivatives of quinazolinone and phthalazinone | BOEHRINGER INGELHEIM GMBH (DE) | 1979-01-16 | — | — | US | disclosed |
| US-4087541-A | REDUCING HEART RATE | BOEHRINGER INGELHEIM GMBH (DT) | 1978-05-02 | — | — | US | disclosed |
| US-4038407-A | HEART RATE SLOWING DRUGS | BOEHRINGER INGELHEIM GMBH (DT) | 1977-07-26 | — | — | US | disclosed |
| US-4021558-A | 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents | BOEHRINGER INGELHEIM GMBH (DT) | 1977-05-03 | — | — | US | disclosed |
| US-3948898-A | HYPOTENSIVES, SEDATIVES, ANTIARRHYTHMICS, BRADYCARDIACS | BOEHRINGER INGELHEIM GMBH (DT) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107243-A1 | Nitro-benzamides useful as Anti-arrhythmic agents | KCNH1, KCNH2, SCN2B | CYP3A4 114/4885CYP1A2 128/4885CYP2D6 64/4885 |
| US-20010025054-A1 | Nitro-benzamides useful as anti-arrhythmic agents | KCNH1, KCNH2, SCN2B | CYP3A4 114/4885CYP1A2 128/4885CYP2D6 64/4885 |
| US-20040266772-A1 | Polymorph salt of a pryridazinone derivative for the treatment of arrythmia | SCN5A, CYP3A5, CYP2C19 | CYP3A4 4/4885CYP1A2 21/4885CYP2D6 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.