SCHEMBL6633239

SCHEMBL6633239

NC(=O)Oc1ncccn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
P2RX7 Q99572 1/20 0.38
APAF1 O14727 1/20 0.35
PARP1 P09874 2/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
NAPRT Q6XQN6 2/20 0.34
RAB9A P51151 2/20 0.33
LMNA P02545 1/20 0.33
P4HTM Q9NXG6 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HSP90AA1 P07900 1/20 0.33
PARP10 Q53GL7 1/20 0.33
NPC1 O15118 1/20 0.33
MITF O75030 1/20 0.33
PKM P14618 1/20 0.33
CDK5 Q00535 1/20 0.33
CDK5R1 Q15078 1/20 0.33
NOS3 P29474 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1161075 0.79 KMT2A (0.37) MEN1KMT2AP2RX7APAF1CES2
SCHEMBL782969 0.78 MEN1 (0.37) MEN1KMT2AP2RX7HSP90AA1
SCHEMBL6157107 0.77 LMNA (0.39) MEN1KMT2AP2RX7CES2CES1
SCHEMBL28960220 0.76 MEN1 (0.35) MEN1KMT2A
Methylamine SCHEMBL536416 0.76 KDM4E (0.41) MEN1KMT2AP2RX7NAPRTLMNA
SCHEMBL31696710 0.75 MEN1 (0.35) MEN1KMT2AAPAF1L3MBTL1HSP90AA1
SCHEMBL6600410 0.75 MEN1 (0.35) MEN1KMT2AP2RX7APAF1CES2
SCHEMBL1291212 0.75 KDM4E (0.43) MEN1KMT2ANAPRTLMNAKDM4E
SCHEMBL19066140 0.75 KDM4E (0.36) MEN1KMT2AKDM4E
SCHEMBL29178970 0.75 MEN1 (0.34) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626958-A1 SULFONYLUREAS AS HERBICIDES CIBA-GEIGY AG (CH) 1994-12-07 EP claimed
WO-1993017016-A1 SULFONYLUREAS AS HERBICIDES CIBA-GEIGY AG (CH) 1993-09-02 WO claimed
US-20190119212-A1 A VERSATILE LIGAND FOR PALLADIUM-CATALYZED META-C-H FUNCTIONALIZATIONS THE SCRIPPS RESEARCH INSTITUTE 2019-04-25 US disclosed
WO-2017184589-A1 A VERSATILE LIGAND FOR PALLADIUM-CATALYZED META-C-H FUNCTIONALIZATIONS THE SCRIPPS RESEARCH INSTITUTE (US) 2017-10-26 WO disclosed
EP-1458374-A2 COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-09-22 EP disclosed
WO-2003051841-A2 COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2003-06-26 WO disclosed
EP-0626958-A1 SULFONYLUREAS AS HERBICIDES CIBA-GEIGY AG (CH) 1994-12-07 EP disclosed
US-5342823-A Herbicides, plant growth regulators CIBA-GEIGY CORPORATION (US) 1994-08-30 US disclosed
WO-1993017016-A1 SULFONYLUREAS AS HERBICIDES CIBA-GEIGY AG (CH) 1993-09-02 WO disclosed
US-4981506-A Herbicides for weed control in rice E. I. DUPONT DE NEMOURS AND COMPANY (US) 1991-01-01 US disclosed
US-4503057-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1985-03-05 US disclosed
EP-0100795-A1 Selected 2-trichloromethyl-4-pyrimidinyl carbamates and their use as fungicides OLIN CORPORATION (US) 1984-02-22 EP disclosed
US-4343803-A FOR PLANTS AND SOILS OLIN CORPORATION (US) 1982-08-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190119212-A1 A VERSATILE LIGAND FOR PALLADIUM-CATALYZED META-C-H FUNCTIONALIZATIONS AHR, PAH, DOHH MEN1 1353/4885KMT2A 1557/4885P2RX7 2915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.