Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | STAT6 | P42226 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858285 | 0.95 | HSD17B10 (0.42) | HSD17B10STAT6CA2FFAR1CA1 | |
| SCHEMBL6635949 | 0.94 | HSD17B10 (0.41) | HSD17B10STAT6CA2FFAR1CA1 | |
| SCHEMBL6635468 | 0.93 | HSD17B10 (0.41) | HSD17B10STAT6CA2FFAR1CA1 | |
| SCHEMBL6217625 | 0.93 | FFAR1 (0.47) | FFAR1SLC22A12 | |
| SCHEMBL6635736 | 0.92 | STAT6 (0.42) | HSD17B10STAT6CA2CA1HSD17B2 | |
| SCHEMBL6860781 | 0.91 | HSD17B10 (0.44) | HSD17B10STAT6CA2CA1HSD17B2 | |
| SCHEMBL6636035 | 0.90 | KDM4E (0.42) | HSD17B10STAT6CA2CA1HSD17B2 | |
| SCHEMBL6212918 | 0.88 | ACHE (0.45) | — | |
| SCHEMBL6762774 | 0.87 | TRPV1 (0.44) | FFAR1 | |
| SCHEMBL6853056 | 0.87 | KDM4E (0.41) | HSD17B10STAT6CA2CA1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189907-B1 | THIENOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2004-12-22 | — | — | EP | claimed |
| US-6787548-B1 | CARDIOVASCULAR INSUFFICIENCY AND ERECTILE DYSFUNCTION; 3-(4-(3-CHLORO-4-HYDROXYBENZYLAMINO) BENZO(4,5)THIENO(2,3-D)PYRIMIDIN-2-YL)PROPIONIC ACID | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2004-09-07 | — | — | US | claimed |
| EP-1189907-A1 | THIENOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GmbH (DE) | 2002-03-27 | — | — | EP | claimed |
| WO-2000078767-A1 | THIENOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2000-12-28 | — | — | WO | claimed |
| EP-1189907-B1 | THIENOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2004-12-22 | — | — | EP | disclosed |
| US-6787548-B1 | CARDIOVASCULAR INSUFFICIENCY AND ERECTILE DYSFUNCTION; 3-(4-(3-CHLORO-4-HYDROXYBENZYLAMINO) BENZO(4,5)THIENO(2,3-D)PYRIMIDIN-2-YL)PROPIONIC ACID | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2004-09-07 | — | — | US | disclosed |
| EP-1189907-A1 | THIENOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GmbH (DE) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000078767-A1 | THIENOPYRIMIDINES AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2000-12-28 | — | — | WO | disclosed |