Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | CPA1 | P15085 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661764 | 1.00 | ACE (0.40) | ACEALDH1A1MMECPA1ACE2 | |
| SCHEMBL6674991 | 1.00 | ACE (0.40) | ACEALDH1A1MMECPA1ACE2 | |
| SCHEMBL4347972 | 0.79 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1TDP1TP53 | |
| SCHEMBL4351614 | 0.79 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1TDP1TP53 | |
| SCHEMBL27849374 | 0.79 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1TDP1TP53 | |
| SCHEMBL21017478 | 0.79 | ACE (0.38) | ACEALDH1A1MMECPA1ACE2 | |
| SCHEMBL12260419 | 0.79 | ACE (0.46) | ACEALDH1A1MMECPA1ACE2 | |
| SCHEMBL13040584 | 0.79 | ACE (0.46) | ACEALDH1A1MMECPA1ACE2 | |
| SCHEMBL2944717 | 0.79 | ACE (0.46) | ACEALDH1A1MMECPA1ACE2 | |
| SCHEMBL27984989 | 0.79 | ACE (0.46) | ACEALDH1A1MMECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | ACE 2/4885ALDH1A1 2104/4885MME 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.