Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 13/20 | 0.51 |
| ▸ | F10 | P00742 | 7/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8027015 | 0.87 | F2 (0.65) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL8026562 | 0.86 | F2 (0.67) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6638105 | 0.86 | F2 (0.57) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6635646 | 0.86 | PPARG (0.43) | F2HDAC6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8028460 | 0.86 | F2 (0.66) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6640816 | 0.75 | F2 (0.61) | F2F10HDAC6PRSS1PRSS2 | |
| SCHEMBL8027045 | 0.74 | F2 (0.45) | F2ALDH1A1 | |
| SCHEMBL6633895 | 0.73 | F2 (0.58) | F2F10HDAC6PRSS1PRSS2 | |
| SCHEMBL8029893 | 0.72 | F2 (0.46) | F2 | |
| SCHEMBL6635980 | 0.72 | SMN1; SMN2 (0.42) | F2F10HDAC6PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100795-B1 | DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6121308-A | INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE | BOEHRINGER INGELHEIM KG (DE) | 2000-09-19 | — | — | US | disclosed |