Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNT1 | Q5JUK3 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5331514 | 0.90 | NTRK1 (0.42) | NTRK1FPR2PROKR1KCNJ6KCNJ3 | |
| SCHEMBL6665547 | 0.88 | SCN9A (0.34) | NTRK1FPR2PROKR1HRH1CCR3 | |
| SCHEMBL6640836 | 0.87 | NTRK1 (0.48) | NTRK1FPR2PROKR1CCR3KCNJ6 | |
| SCHEMBL6636325 | 0.81 | FPR2 (0.38) | NTRK1FPR2PROKR1HRH1CCR3 | |
| SCHEMBL6635325 | 0.78 | MAPT (0.45) | MEN1KMT2ATP53 | |
| SCHEMBL6637614 | 0.77 | NTRK1 (0.42) | NTRK1FPR2PROKR1KCNJ6KCNJ3 | |
| SCHEMBL5333712 | 0.77 | MAPT (0.36) | NTRK1FPR2PROKR1ACACBMEN1 | |
| SCHEMBL5219563 | 0.77 | NTRK1 (0.41) | NTRK1KCNJ6KCNJ3KCNJ5CYP3A4 | |
| SCHEMBL5219567 | 0.77 | NTRK1 (0.41) | NTRK1KCNJ6KCNJ3KCNJ5CYP3A4 | |
| SCHEMBL5218970 | 0.77 | CYP3A4 (0.42) | NTRK1KCNJ6KCNJ3KCNJ5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487435-A1 | AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003077907-A1 | AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2003-09-25 | — | — | WO | disclosed |