Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451551 | 0.90 | MEN1 (0.50) | MAOAMAOBMEN1KMT2ACHRM2 | |
| SCHEMBL6632600 | 0.85 | ALOX15 (0.50) | ALOX15HSD17B10MAOAMAOBCYP1A2 | |
| SCHEMBL16428483 | 0.81 | CYP2D6 (0.53) | KMT2ALTA4HOPRD1CYP2D6 | |
| SCHEMBL30108220 | 0.76 | CHRM2 (0.66) | MEN1KMT2ACHRM2CHRM1SLC6A2 | |
| SCHEMBL3160983 | 0.74 | CHRNB4 (0.49) | ALOX15HSD17B10MAOAMAOBCYP1A2 | |
| SCHEMBL14966522 | 0.73 | CHRNB4 (0.47) | CYP1A2GAACYP2C9CYP2C19MEN1 | |
| SCHEMBL4322787 | 0.73 | CHRNB4 (0.47) | CYP1A2GAACYP2C9CYP2C19MEN1 | |
| SCHEMBL5387820 | 0.71 | CHRNB4 (0.42) | ALOX15HSD17B10MAOAMAOBCYP1A2 | |
| SCHEMBL5388787 | 0.71 | CHRNB4 (0.46) | ALOX15HSD17B10MEN1KMT2ASLC6A2 | |
| SCHEMBL6255523 | 0.71 | MEN1 (0.56) | MEN1KMT2ACHRM2CHRM1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463731-A1 | DIBENZODIAZEPINE DERIVATES, THEIR PREPARATION AND USE | Abbott GmbH & Co. KG (DE) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003057699-A1 | DIBENZODIAZEPINE DERIVATES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |