Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNG | P07510 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966522 | 1.00 | CHRNB4 (0.47) | CHRNB4CHRNA3CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL3160983 | 0.98 | CHRNB4 (0.49) | CHRNB4CHRNA3CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL6632600 | 0.87 | ALOX15 (0.50) | CYP2C19CYP1A2CYP2C9KCNH2LTA4H | |
| SCHEMBL5387820 | 0.83 | CHRNB4 (0.42) | CHRNB4CHRNA3CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL5111199 | 0.81 | ALDH1A1 (0.33) | CHRNB4CHRNA3CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL5122546 | 0.81 | ALDH1A1 (0.33) | CHRNB4CHRNA3CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL7451551 | 0.81 | MEN1 (0.50) | CHRNB4CHRNA3CYP2D6KCNH2LTA4H | |
| SCHEMBL5115964 | 0.81 | ALDH1A1 (0.33) | CHRNB4CHRNA3CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL6731066 | 0.81 | SIGMAR1 (0.43) | KMT2AALDH1A1LMNA | |
| SCHEMBL5122082 | 0.81 | ALDH1A1 (0.33) | CHRNB4CHRNA3CYP2D6CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867207-B1 | PHENOXYETHYL PIPERIDINE COMPOUNDS | LILLY CO ELI (US) | 2017-08-09 | — | — | EP | disclosed |
| CN-104411684-B | Phenoxyethyl piperidine compounds | 伊莱利利公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104411684-B | Phenoxyethyl piperidine compounds | 伊莱利利公司 | 2016-08-24 | — | — | CN | disclosed |
| US-9402838-B2 | Phenoxyethyl piperidine compounds | ELI LILLY AND COMPANY (US) | 2016-08-02 | — | — | US | disclosed |
| US-9402838-B2 | Phenoxyethyl piperidine compounds | ELI LILLY AND COMPANY (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150126555-A1 | PHENOXYETHYL PIPERIDINE COMPOUNDS | ELANCO US INC. | 2015-05-07 | — | — | US | disclosed |
| EP-2867207-A1 | PHENOXYETHYL PIPERIDINE COMPOUNDS | Eli Lilly and Company (US) | 2015-05-06 | — | — | EP | disclosed |
| CN-104411684-A | Phenoxyethyl piperidine compounds | LILLY CO ELI | 2015-03-11 | — | — | CN | disclosed |
| CN-104411684-A | Phenoxyethyl piperidine compounds | LILLY CO ELI | 2015-03-11 | — | — | CN | disclosed |
| US-8962659-B2 | Phenoxyethyl piperidine compounds | ELI LILLY AND COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| US-8962659-B2 | Phenoxyethyl piperidine compounds | ELI LILLY AND COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| WO-2014004229-A1 | PHENOXYETHYL PIPERIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-01-03 | — | — | WO | disclosed |
| US-20140005226-A1 | PHENOXYETHYL PIPERIDINE COMPOUNDS | ELANCO US INC. | 2014-01-02 | — | — | US | disclosed |
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
| EP-1833800-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005226-A1 | PHENOXYETHYL PIPERIDINE COMPOUNDS | EP300, HRH3, H1-2 | CHRNB4 2552/4885CHRNA3 1359/4885CYP2D6 958/4885 |
| US-20150126555-A1 | PHENOXYETHYL PIPERIDINE COMPOUNDS | EP300, HRH3, H1-2 | CHRNB4 2552/4885CHRNA3 1359/4885CYP2D6 958/4885 |
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | GRIN1, GRM1, GRIN3A | CHRNB4 135/4885CHRNA3 46/4885CYP2D6 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.