Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 4/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15373652 | 0.71 | PNMT (0.45) | CMA1AHRBRD4PNMTADRA2A | |
| SCHEMBL31076226 | 0.71 | BRD4 (0.41) | CMA1AHRBRD4PNMTADRA2A | |
| SCHEMBL1396641 | 0.69 | BRD4 (0.44) | CMA1AHRBRD4PNMTADRA2A | |
| SCHEMBL2988989 | 0.68 | ALOX15 (0.63) | CMA1AHRBRD4SLC6A2HTR2A | |
| SCHEMBL24424921 | 0.68 | TDP1 (0.43) | CMA1AHRSLC6A2HTR2AHTR2C | |
| SCHEMBL29620728 | 0.68 | TDP1 (0.43) | CMA1AHRSLC6A2HTR2AHTR2C | |
| SCHEMBL6615558 | 0.66 | HSD17B3 (0.43) | BRD4IDH1LMNA | |
| SCHEMBL12280375 | 0.66 | PNMT (0.50) | CMA1AHRPNMTADRA2AADRA2B | |
| SCHEMBL290721 | 0.65 | PNMT (0.48) | CMA1AHRBRD4PNMTADRA2A | |
| SCHEMBL17252188 | 0.65 | CMA1 (0.43) | CMA1AHRBRD4PNMTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6455523-B1 | ADMINISTERING 1,4-BENZODIAZEPINE DERIVATIVE AS ANTITUMOR OR ANTICARCINOGENIC AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-24 | — | — | US | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |