Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976924 | 0.91 | NOD1 (0.47) | NOD1KDRSLC2A1 | |
| SCHEMBL4977121 | 0.91 | KDR (0.47) | CYP1A2CYP2C9CYP2C19KDM4ELMNA | |
| SCHEMBL4978076 | 0.89 | NOD1 (0.44) | HTTNOD1MEN1KMT2ACYP1A2 | |
| SCHEMBL4978206 | 0.89 | KDR (0.40) | POLBKDM4ELMNASMN1; SMN2KDR | |
| SCHEMBL4980906 | 0.89 | KDR (0.42) | KDM4EL3MBTL1LMNAKDRSLC2A1 | |
| SCHEMBL4978451 | 0.89 | KDM4E (0.45) | NOD1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL4979259 | 0.88 | KDR (0.42) | HTTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL4978778 | 0.88 | SLC2A1 (0.43) | HTTKDM4EL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL4980467 | 0.87 | TP53 (0.51) | HTTMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL4978436 | 0.87 | ROCK2 (0.43) | KDM4ELMNASMN1; SMN2KDRSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003074515-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |