Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597291 | 0.81 | ALDH1A1 (0.50) | HTTSMN1; SMN2NPBWR1ALDH1A1MAPT | |
| SCHEMBL30992791 | 0.81 | NPBWR1 (0.51) | SMN1; SMN2NPBWR1ALDH1A1MAPTKDM4E | |
| SCHEMBL16014712 | 0.79 | NPBWR1 (0.47) | HTTNPSR1L3MBTL1SMN1; SMN2NPBWR1 | |
| SCHEMBL3296364 | 0.77 | NPBWR1 (0.45) | SMN1; SMN2NPBWR1ALDH1A1MAPTKDM4E | |
| SCHEMBL7480360 | 0.77 | NPBWR1 (0.45) | NPSR1SMN1; SMN2NPBWR1ALDH1A1MAPT | |
| SCHEMBL3296219 | 0.75 | TAAR1 (0.51) | SMN1; SMN2NPBWR1ALDH1A1MAPTKDM4E | |
| SCHEMBL3296213 | 0.75 | ALDH1A1 (0.43) | NPSR1L3MBTL1SMN1; SMN2NPBWR1ALDH1A1 | |
| SCHEMBL29208868 | 0.72 | ALDH1A1 (0.47) | NPSR1SMN1; SMN2NPBWR1ALDH1A1MAPT | |
| SCHEMBL30402448 | 0.72 | ALDH1A1 (0.47) | NPSR1SMN1; SMN2NPBWR1ALDH1A1MAPT | |
| SCHEMBL8445010 | 0.71 | DAO (0.53) | HTTNPSR1L3MBTL1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280806-B1 | THIENO 2,3-d]PYRIMIDINEDIONES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2004-08-04 | — | — | EP | disclosed |
| US-20040014634-A1 | Thieno[2,3-d]pyrimidinediones and their use as pharmaceuticals | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014634-A1 | Thieno[2,3-d]pyrimidinediones and their use as pharmaceuticals | DPYD, TYMP, TYMS | HTT 3802/4885NPSR1 1466/4885L3MBTL1 3860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.