Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 10/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.65 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637930 | 0.94 | HDAC1 (0.58) | HDAC3HDAC1HDAC2PLK1HDAC8 | |
| SCHEMBL1093718 | 0.85 | TSHR (0.73) | HDAC3HDAC1HDAC2PLK1HDAC8 | |
| SCHEMBL30301313 | 0.85 | TSHR (0.73) | HDAC3HDAC1HDAC2PLK1HDAC8 | |
| SCHEMBL6635281 | 0.84 | PLK1 (0.62) | PLK1HDAC8MMP3MEN1KMT2A | |
| SCHEMBL14058606 | 0.81 | TSHR (0.66) | PLK1HDAC8MMP3CNR1CNR2 | |
| SCHEMBL27295235 | 0.81 | HDAC3 (0.67) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL6634756 | 0.80 | HDAC3 (0.70) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL1286894 | 0.79 | NAAA (0.67) | PLK1HDAC8MMP3CNR1CNR2 | |
| SCHEMBL27801490 | 0.79 | NAAA (0.67) | PLK1HDAC8MMP3CNR1CNR2 | |
| SCHEMBL3238026 | 0.79 | NAAA (0.67) | PLK1HDAC8MMP3CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2020-12-22 | — | — | US | disclosed |
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190308932-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2019-10-10 | — | — | US | disclosed |
| US-20190308932-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2019-10-10 | — | — | US | disclosed |
| EP-1420044-A2 | Rubber composition and pneumatic tire | Bridgestone Corporation (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6380288-B1 | LOW HEAT GENERATION PROPERTY, AGING REISTANCE, ALSO FOR PRODUCING VIBRATION ISOLATORS, BELTS AND HOSES AS WELL AS TIRE MATERIALS SUCH AS TIRE TREADS, UNDERTREADS, CARCASSES, SIDE WALLS AND BEADS | BRIDGESTONE CORPORATION | 2002-04-30 | — | — | US | disclosed |
| EP-0909788-A1 | RUBBER COMPOSITION AND PNEUMATIC TIRES | Bridgestone Corporation (JP) | 1999-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC1 1/4885HDAC2 7/4885 |
| US-20190308932-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC1 1/4885HDAC2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.