SCHEMBL6636112

SCHEMBL6636112

CCCN(C)c1cc(N(NC(=O)CC(=O)c2cccc(-c3cc(C)no3)c2)C(=O)OC(C)(C)C)ccc1C#N

nearest known ligand 0.32

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PGR P06401 1/20 0.32
MAPT P10636 4/20 0.32
DRD2 P14416 2/20 0.32
DRD3 P35462 2/20 0.32
RET P07949 1/20 0.31
HDAC3 O15379 2/20 0.31
HDAC1 Q13547 2/20 0.31
HDAC2 Q92769 2/20 0.31
HDAC10 Q969S8 2/20 0.31
HDAC8 Q9BY41 2/20 0.31
HDAC6 Q9UBN7 2/20 0.31
TP53 P04637 1/20 0.31
PRKD1 Q15139 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC11 Q96DB2 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6166066 0.81 HDAC6 (0.37) MAPTDRD2DRD3RETHDAC3
SCHEMBL5566520 0.76 RXRA (0.32)
SCHEMBL6166955 0.74 HDAC6 (0.40) MAPTDRD2DRD3HDAC3HDAC1
SCHEMBL6165406 0.73 HDAC6 (0.39) MAPTDRD2DRD3RETHDAC3
SCHEMBL6164325 0.73 HDAC6 (0.40) MAPTDRD2DRD3RETHDAC3
SCHEMBL6163299 0.72 HDAC6 (0.38) DRD2DRD3RETHDAC3HDAC1
SCHEMBL6164185 0.72 HDAC6 (0.37) DRD2DRD3RETHDAC3HDAC1
SCHEMBL6165382 0.72 HDAC6 (0.38) MAPTDRD2DRD3HDAC3HDAC1
SCHEMBL5869159 0.71 HDAC6 (0.41) MAPTDRD2DRD3HDAC3HDAC1
SCHEMBL6163761 0.68 HDAC6 (0.41) MAPTDRD2DRD3HDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1379511-A1 DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II F. HOFFMANN-LA ROCHE AG (CH) 2004-01-14 EP disclosed
WO-2002083652-A1 DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II F. HOFFMANN-LA ROCHE AG (CH) 2002-10-24 WO disclosed