Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636718 | 0.83 | POLB (0.47) | POLBHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL1233566 | 0.74 | SMN1; SMN2 (0.53) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6641070 | 0.74 | ALPL (0.43) | POLBKMT2AHPGD | |
| Hydrochloric Acid SCHEMBL27528526 | 0.73 | SMN1; SMN2 (0.51) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL14424273 | 0.73 | POLB (0.45) | POLBHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL13203880 | 0.73 | NPY5R (0.49) | POLBHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL10113376 | 0.73 | NPY5R (0.49) | POLBHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL10114842 | 0.73 | POLB (0.45) | POLBHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL6640469 | 0.71 | TDP1 (0.66) | POLBMEN1KMT2ASIRT5 | |
| SCHEMBL29663729 | 0.70 | MAPT (0.69) | POLBMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250340-B1 | METHODS AND COMPOUNDS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-1250340-A1 | METHODS AND COMPOUNDS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001046199-A1 | METHODS AND COMPOUNDS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |