Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636713 | 0.83 | POLB (0.50) | POLBTSHRALDH1A1MAPTHSD17B10 | |
| SCHEMBL6641070 | 0.80 | ALPL (0.43) | POLBTP53ALPLALPIALPG | |
| SCHEMBL6639898 | 0.72 | SMN1; SMN2 (0.46) | POLBTSHRALDH1A1MAPTGFER | |
| SCHEMBL6639133 | 0.72 | SMN1; SMN2 (0.46) | POLBTSHRALDH1A1MAPTGFER | |
| SCHEMBL6639139 | 0.72 | SMN1; SMN2 (0.46) | POLBTSHRALDH1A1MAPTGFER | |
| SCHEMBL6639136 | 0.72 | SMN1; SMN2 (0.46) | POLBTSHRALDH1A1MAPTGFER | |
| SCHEMBL6639904 | 0.72 | SMN1; SMN2 (0.46) | POLBTSHRALDH1A1MAPTGFER | |
| SCHEMBL8595938 | 0.71 | MTNR1A (0.59) | POLBALDH1A1MAPT | |
| SCHEMBL8597711 | 0.71 | MTNR1A (0.59) | POLBALDH1A1MAPT | |
| SCHEMBL29663729 | 0.71 | MAPT (0.69) | POLBALDH1A1MAPTGFERTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250340-B1 | METHODS AND COMPOUNDS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-1250340-A1 | METHODS AND COMPOUNDS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001046199-A1 | METHODS AND COMPOUNDS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |