Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 6/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.37 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663757 | 1.00 | CYP2C19 (0.59) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL1881392 | 1.00 | CYP2C19 (0.59) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL5673666 | 1.00 | CYP2C19 (0.59) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL30874729 | 0.99 | CYP2C19 (0.58) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL8783194 | 0.99 | CYP2C19 (0.58) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL30505546 | 0.95 | CYP2C19 (0.54) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL10040348 | 0.94 | CYP2C19 (0.56) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL17295969 | 0.91 | CYP2C19 (0.53) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL6057504 | 0.87 | CYP2C19 (0.78) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR | |
| SCHEMBL24425958 | 0.87 | CYP2D6 (0.77) | CYP2C19CYP2D6CYP1A2CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110196175-A1 | Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts | FMC CORPORATION | 2011-08-11 | — | — | US | claimed |
| EP-3271344-B1 | PROCESS FOR PREPARING AMINOTETRAHYDROPYRANS | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2020-08-26 | — | — | EP | disclosed |
| US-10377732-B2 | Process for preparing aminotetrahydropyrans | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-08-13 | — | — | US | disclosed |
| US-20180290995-A1 | Process For Preparing Aminotetrahydropyrans | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2018-10-11 | — | — | US | disclosed |
| US-8889873-B2 | Process for the preparation of enantiomerically enriched proton pump inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2014-11-18 | — | — | US | disclosed |
| US-8889873-B2 | Process for the preparation of enantiomerically enriched proton pump inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2014-11-18 | — | — | US | disclosed |
| US-8889873-B2 | Process for the preparation of enantiomerically enriched proton pump inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2014-11-18 | — | — | US | disclosed |
| US-8410295-B2 | Method for production of optically active epoxy compound, and complex used therefor and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2013-04-02 | — | — | US | disclosed |
| US-8258345-B2 | Hydroxylation of β-dicarbonyls with zirconium catalysts | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-09-04 | — | — | US | disclosed |
| US-20120178954-A1 | METHOD FOR PRODUCTION OF OPTICALLY ACTIVE EPOXY COMPOUND, AND COMPLEX USED THEREFOR AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2012-07-12 | — | — | US | disclosed |
| US-20110196175-A1 | Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts | FMC CORPORATION | 2011-08-11 | — | — | US | disclosed |
| US-7939685-B2 | Hydroxylation of β-dicarbonyls with zirconium catalysts | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-05-10 | — | — | US | disclosed |
| EP-2264024-A1 | Process for the preparation of enantiomerically enriched proton pump inhibitors | LEK Pharmaceuticals d.d. (SI) | 2010-12-22 | — | — | EP | disclosed |
| US-20100185014-A1 | Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts | FMC CORPORATION | 2010-07-22 | — | — | US | disclosed |
| US-7718818-B2 | Hydroxylation of beta-dicarbonyls with zirconium catalysts | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-05-18 | — | — | US | disclosed |
| WO-2010043601-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED PROTON PUMP INHIBITORS | LEK PHARMACEUTICALS D.D. (SI) | 2010-04-22 | — | — | WO | disclosed |
| US-20080306259-A1 | HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS | FMC CORPORATION | 2008-12-11 | — | — | US | disclosed |
| US-7414157-B2 | Hydroxylation of β-dicarbonyls with zirconium catalysts | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1401575-B1 | HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS | DU PONT (US) | 2007-01-17 | — | — | EP | disclosed |
| US-20040143123-A1 | Hydroxylation of beta-dicarbonyls with zirconium catalysts | FMC CORPORATION | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100185014-A1 | Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts | CBR3, CBR1, NOXO1 | CYP2C19 337/4885CYP2D6 176/4885CYP1A2 135/4885 |
| US-20040143123-A1 | Hydroxylation of beta-dicarbonyls with zirconium catalysts | CBR1, CBR3, NOXO1 | CYP2C19 429/4885CYP2D6 48/4885CYP1A2 114/4885 |
| US-10377732-B2 | Process for preparing aminotetrahydropyrans | DPP4, DPP3, DPP9 | CYP2C19 193/4885CYP2D6 61/4885CYP1A2 288/4885 |
| US-20110196175-A1 | Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts | CBR3, CBR1, NOXO1 | CYP2C19 337/4885CYP2D6 176/4885CYP1A2 135/4885 |
| US-20080306259-A1 | HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS | CBR3, CBR1, ASPH | CYP2C19 306/4885CYP2D6 112/4885CYP1A2 123/4885 |
| US-20180290995-A1 | Process For Preparing Aminotetrahydropyrans | DPP4, DPP3, DPP9 | CYP2C19 193/4885CYP2D6 61/4885CYP1A2 288/4885 |
| US-20120178954-A1 | METHOD FOR PRODUCTION OF OPTICALLY ACTIVE EPOXY COMPOUND, AND COMPLEX USED THEREFOR AND PROCESS FOR PRODUCING THE SAME | CYP4F11, CYP51A1, COASY | CYP2C19 609/4885CYP2D6 341/4885CYP1A2 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.