Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TERT | O14746 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658713 | 0.91 | TAAR1 (0.54) | TAAR1GAAMAPTHRH4MEN1 | |
| SCHEMBL2475485 | 0.85 | TAAR1 (0.62) | TAAR1GAAMAPTMEN1KMT2A | |
| SCHEMBL4775864 | 0.83 | TERT (0.59) | TAAR1TERTPDCD1LG2CD274 | |
| SCHEMBL12807572 | 0.80 | TERT (0.66) | TAAR1TERTPDCD1LG2CD274 | |
| SCHEMBL570036 | 0.79 | TAAR1 (0.69) | TAAR1TERTCYP2D6TSHRLMNA | |
| Hydrochloric Acid SCHEMBL1846181 | 0.78 | TAAR1 (0.67) | TAAR1TERTCYP2D6TSHRLMNA | |
| SCHEMBL9666999 | 0.77 | TAAR1 (0.70) | TAAR1GAAMAPTMEN1KMT2A | |
| SCHEMBL15121693 | 0.76 | TAAR1 (0.65) | TAAR1TERTCYP2D6TSHRLMNA | |
| SCHEMBL8958092 | 0.76 | TAAR1 (0.65) | TAAR1TERTCYP2D6TSHRLMNA | |
| SCHEMBL9370948 | 0.76 | POLB (0.49) | TAAR1HRH4TERTCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-A4 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1322309-A2 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | Neurogen Corporation (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002049993-A2 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |