Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.53 |
| ▸ | SRC | P12931 | 10/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17119637 | 0.80 | CHEK1 (0.51) | FGFR1SRCCHEK1FGFR4PTGES | |
| SCHEMBL8142094 | 0.79 | FGFR1 (0.55) | FGFR1SRCCHEK1EGFRFGFR2 | |
| SCHEMBL10276720 | 0.79 | FGFR1 (0.65) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL6643371 | 0.74 | FGFR1 (0.43) | FGFR1SRCCHEK1GRIN2DGRIN3B | |
| SCHEMBL5619944 | 0.74 | SRC (0.56) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL6640886 | 0.72 | FGFR1 (0.73) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL8143371 | 0.72 | FGFR1 (0.67) | FGFR1SRCCHEK1EGFRFGFR2 | |
| SCHEMBL5659394 | 0.71 | FGFR1 (0.45) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL29536840 | 0.71 | FGFR1 (0.45) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL22538244 | 0.70 | FGFR1 (0.47) | FGFR1SRCCHEK1EGFRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | disclosed |