Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 13/20 | 0.65 |
| ▸ | SRC | P12931 | 12/20 | 0.65 |
| ▸ | WEE1 | P30291 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986331 | 0.80 | FGFR1 (0.61) | FGFR1SRCWEE1EGFRFGFR4 | |
| SCHEMBL6639245 | 0.79 | FGFR1 (0.53) | FGFR1SRCEGFRFGFR4FGFR2 | |
| Ethane SCHEMBL5761899 | 0.78 | FGFR1 (0.62) | FGFR1SRCWEE1EGFRFGFR4 | |
| SCHEMBL6642129 | 0.75 | FGFR1 (1.00) | FGFR1SRCWEE1EGFRFGFR4 | |
| Ethane SCHEMBL5793409 | 0.74 | WEE1 (0.54) | FGFR1SRCWEE1EGFRFGFR4 | |
| SCHEMBL8128174 | 0.73 | FGFR1 (0.47) | FGFR1SRCEGFRAURKACCNA2 | |
| SCHEMBL8142094 | 0.72 | FGFR1 (0.55) | FGFR1SRCEGFRFGFR4FGFR2 | |
| SCHEMBL5332258 | 0.72 | FGFR1 (0.48) | FGFR1SRCWEE1AURKACCNA2 | |
| SCHEMBL30880085 | 0.71 | TTK (0.56) | AURKACCNA2CDK2TTK | |
| SCHEMBL27197108 | 0.71 | TTK (0.56) | AURKACCNA2CDK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178180-A1 | METHODS FOR THE IDENTIFICATION OF ZAP-70 INTERACTING MOLECULES AND FOR THE PURIFICATION OF ZAP-70 | CELLZOME GMBH (DE) | 2012-07-12 | — | — | US | disclosed |