SCHEMBL6639629

SCHEMBL6639629

COC(=O)C(C)Oc1ncccc1Oc1cc(N)c(F)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.40
CARM1 Q86X55 3/20 0.39
PRMT6 Q96LA8 2/20 0.39
MAPT P10636 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MET P08581 1/20 0.38
SCN9A Q15858 1/20 0.37
P2RY1 P47900 1/20 0.37
MAP2 P11137 2/20 0.37
ROCK2 O75116 2/20 0.35
ALK Q9UM73 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6639805 0.90 PPOX (0.41) MAPK8CARM1PRMT6KMT2AL3MBTL1
SCHEMBL6638772 0.85 P2RY1 (0.41) MAPK8CARM1PRMT6MAPTMEN1
SCHEMBL6639707 0.84 MAPT (0.37) MAPK8CARM1PRMT6MAPTMEN1
SCHEMBL6666269 0.82 MAPT (0.38) MAPK8CARM1PRMT6MAPTMEN1
SCHEMBL3250748 0.81 MAPK8 (0.43) MAPK8CARM1PRMT6MAPTSCN9A
SCHEMBL8599623 0.80 PPOX (0.42) MAPTMEN1KMT2AL3MBTL1
SCHEMBL6640646 0.79 P2RY1 (0.41) CARM1PRMT6MAPTMEN1KMT2A
SCHEMBL6640252 0.79 MEN1 (0.38) MAPTMEN1KMT2AL3MBTL1MET
SCHEMBL30704857 0.78 PPOX (0.41) MAPK8CARM1MEN1KMT2AL3MBTL1
SCHEMBL30704856 0.78 PPOX (0.41) MAPK8CARM1MEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1122244-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2004-09-29 EP claimed
US-6537948-B1 Have a wide range of herbicidal spectrum, and causes no phytotoxicity on crops SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-25 US claimed
EP-1122244-A1 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-08 EP claimed
EP-1122244-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2004-09-29 EP disclosed
US-6537948-B1 Have a wide range of herbicidal spectrum, and causes no phytotoxicity on crops SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-25 US disclosed
EP-1122244-A1 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-08 EP disclosed