SCHEMBL6640646

SCHEMBL6640646

COC(=O)C(C)Oc1ncccc1Oc1cc(NC(C)=O)c(F)cc1N

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 7/20 0.41
MAPT P10636 2/20 0.40
ATM Q13315 1/20 0.39
CARM1 Q86X55 2/20 0.38
PRMT6 Q96LA8 1/20 0.38
DHODH Q02127 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6637735 0.92 P2RY1 (0.40) P2RY1MAPTATMCARM1PRMT6
SCHEMBL6638772 0.89 P2RY1 (0.41) P2RY1MAPTATMCARM1PRMT6
SCHEMBL6639108 0.85 MEN1 (0.46) P2RY1MAPTATMNPSR1RAB9A
SCHEMBL3244227 0.82 ATM (0.42) P2RY1MAPTATMCARM1PRMT6
SCHEMBL6642262 0.80 P2RY1 (0.40) P2RY1MAPTCARM1PRMT6DHODH
SCHEMBL6640929 0.80 P2RY1 (0.41) P2RY1MAPTATMCARM1NPC1
SCHEMBL14639177 0.80 P2RY1 (0.43) P2RY1MAPTATMCARM1PRMT6
SCHEMBL6639629 0.79 MAPK8 (0.40) P2RY1MAPTCARM1PRMT6MEN1
SCHEMBL6636160 0.78 KMT2A (0.44) P2RY1MAPTNPSR1NPC1RAB9A
SCHEMBL6248183 0.73 CA1 (0.43) MAPTNPC1RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1122244-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2004-09-29 EP disclosed
US-6537948-B1 Have a wide range of herbicidal spectrum, and causes no phytotoxicity on crops SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-25 US disclosed
EP-1122244-A1 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-08 EP disclosed