Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.81 |
| ▸ | NPC1 | O15118 | 3/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MGAM | O43451 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | SI | P14410 | 3/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.52 |
| ▸ | DCK | P27707 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16920970 | 0.90 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2MGAMGAA | |
| SCHEMBL1520770 | 0.84 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2GAAMAPT | |
| SCHEMBL6639098 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2MGAMGAA | |
| SCHEMBL6641196 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2GAATP53 | |
| SCHEMBL1520700 | 0.83 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2MGAMGAA | |
| SCHEMBL6640347 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2GAALMNA | |
| SCHEMBL6354561 | 0.83 | MEN1 (0.56) | RAB9ANPC1SMN1; SMN2CTSBMAPT | |
| SCHEMBL6642566 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2MAPTLMNA | |
| SCHEMBL489638 | 0.82 | MEN1 (0.54) | RAB9ANPC1SMN1; SMN2DCKTP53 | |
| SCHEMBL8139592 | 0.81 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449835-A2 | Alpha-substituted pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1247804-A1 | Pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |