Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636007 | 0.84 | RAB9A (0.79) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1520770 | 0.84 | RAB9A (0.78) | RAB9ANPC1SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6639637 | 0.83 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL6640141 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6354561 | 0.83 | MEN1 (0.56) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6641196 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL6639098 | 0.83 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL6643095 | 0.83 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL8182079 | 0.82 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6642566 | 0.80 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449835-A2 | Alpha-substituted pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1247804-A1 | Pyrimidine-thioalkyl and alkylether compounds | PHARMACIA & UPJOHN COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |