Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6639062 | 0.89 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11SCN9A | |
| SCHEMBL6638727 | 0.85 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6640668 | 0.85 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6640919 | 0.84 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL6638898 | 0.84 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11SCN9A | |
| SCHEMBL6639556 | 0.83 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6639354 | 0.83 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6638761 | 0.83 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6642176 | 0.82 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL7627197 | 0.82 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948495-B1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | AMGEN INC (US) | 2004-04-14 | — | — | EP | claimed |
| US-20030096819-A1 | Aryl and heteroaryl substituted fused pyrrole anti-inflammatory agents | AMGEN INC. | 2003-05-22 | — | — | US | claimed |
| US-6180643-B1 | ANTAGONIST OF INTERLEUKINS, TUMOR NECROSIS FACTOR | AMGEN INC. | 2001-01-30 | — | — | US | claimed |
| WO-1998022457-A9 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | — | 1998-08-20 | — | — | WO | claimed |
| EP-0948495-B1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | AMGEN INC (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6605634-B2 | Tumor necrosis factor alpha and interleukin-1 (IL-1) mediated diseases; pain, diabetes; cyclooxygenase inhibition | AMGEN, INC. | 2003-08-12 | — | — | US | disclosed |
| US-20030096819-A1 | Aryl and heteroaryl substituted fused pyrrole anti-inflammatory agents | AMGEN INC. | 2003-05-22 | — | — | US | disclosed |
| US-6440973-B1 | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents | AMGEN INC. | 2002-08-27 | — | — | US | disclosed |
| US-6180643-B1 | ANTAGONIST OF INTERLEUKINS, TUMOR NECROSIS FACTOR | AMGEN INC. | 2001-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096819-A1 | Aryl and heteroaryl substituted fused pyrrole anti-inflammatory agents | TNF, IL1A, IL6 | MAPK14 2705/4885MAPK13 2534/4885MAPK12 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.