Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19187751 | 0.73 | HSD11B1 (0.30) | HSD11B1 | |
| SCHEMBL1896319 | 0.69 | MEN1 (0.40) | HSD11B1EPHX2HCAR1ALDH1A1MEN1 | |
| SCHEMBL14992796 | 0.68 | ALDH1A1 (0.38) | HSD11B1EPHX2HCAR1ALDH1A1MEN1 | |
| SCHEMBL26605404 | 0.67 | ALDH1A1 (0.50) | HSD11B1EPHX2HCAR1ALDH1A1MEN1 | |
| SCHEMBL7358160 | 0.67 | ALDH1A1 (0.50) | HSD11B1EPHX2HCAR1ALDH1A1MEN1 | |
| SCHEMBL206785 | 0.67 | MEN1 (0.49) | HSD11B1EPHX2ALDH1A1MEN1KMT2A | |
| SCHEMBL26605861 | 0.67 | ALDH1A1 (0.50) | HSD11B1EPHX2HCAR1ALDH1A1MEN1 | |
| SCHEMBL4500488 | 0.65 | MEN1 (0.44) | HSD11B1EPHX2MEN1KMT2APOLB | |
| SCHEMBL19188503 | 0.65 | — | — | |
| SCHEMBL19189131 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757685-B1 | NOVEL ACYCLIC AND CYCLIC AMIDES AS NEUROTRANSMITTER RELEASE ENHANCERS | PFIZER (US) | 2004-07-21 | — | — | EP | disclosed |
| US-5854232-A | Acyclic anc cyclic amides as neurotransmitter release enhancers | PFIZER INC. (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0757685-A1 | NOVEL ACYCLIC AND CYCLIC AMIDES AS NEUROTRANSMITTER RELEASE ENHANCERS | PFIZER INC. (US) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029909-A1 | NOVEL ACYCLIC AND CYCLIC AMIDES AS NEUROTRANSMITTER RELEASE ENHANCERS | PFIZER INC. (US) | 1995-11-09 | — | — | WO | disclosed |