Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974591 | 0.86 | CYP3A4 (0.54) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL30458203 | 0.86 | CYP3A4 (0.54) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL17278085 | 0.83 | MAPT (0.45) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL16431495 | 0.80 | APAF1 (0.48) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL1536597 | 0.78 | TNF (0.48) | TNFSRCCGASCYP3A4PDE10A | |
| SCHEMBL16431829 | 0.77 | APAF1 (0.48) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL14538274 | 0.77 | TRPA1 (0.54) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL31589356 | 0.74 | TNF (0.57) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL5358941 | 0.74 | TNF (0.57) | TNFCYP3A4PDE10ASMN1; SMN2ACHE | |
| SCHEMBL8271696 | 0.73 | TRPA1 (0.51) | TNFSRCCYP3A4PDE10ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867436-B1 | N-aryl-piperidine derivatives and their use as 5-HT1B receptor ligands | SERVIER LAB (FR) | 2004-06-09 | — | — | EP | disclosed |
| US-5965575-A | N-aryl piperidine compounds as 5HT1B antagonists | ADIR ET COMPAGNIE (FR) | 1999-10-12 | — | — | US | disclosed |
| EP-0867436-A1 | N-aryl-piperidine derivatives and their use as 5-HT1B receptor ligands | ADIR ET COMPAGNIE (FR) | 1998-09-30 | — | — | EP | disclosed |