Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14742284 | 0.85 | LTA4H (0.40) | LTA4HPIM1PIM2 | |
| SCHEMBL6053357 | 0.84 | CHRNB4 (0.50) | PIM1PIM2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL6619246 | 0.82 | HRH3 (0.40) | LTA4HPIM1PIM2 | |
| SCHEMBL1476215 | 0.81 | SLC6A2 (0.49) | LTA4HPIM1PIM2CHRNB4CHRNA3 | |
| SCHEMBL6207681 | 0.78 | LTA4H (0.47) | LTA4HPOLB | |
| SCHEMBL11456123 | 0.77 | SLC6A2 (0.53) | PIM1PIM2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL2265168 | 0.76 | LTA4H (0.46) | LTA4HPOLB | |
| SCHEMBL28331577 | 0.73 | PARP10 (0.40) | — | |
| SCHEMBL11457727 | 0.73 | PIM1 (0.49) | LTA4HPIM1PIM2CHRNB4CHRNA3 | |
| SCHEMBL4705249 | 0.73 | SLC6A2 (0.39) | CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |