Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491869 | 0.84 | CHRNB4 (0.39) | CHRNB4CHRNA3PRKCZHPGDMKNK1 | |
| SCHEMBL5239690 | 0.84 | SSTR2 (0.41) | SLC6A2CHRNB4CHRNA3PRKCZHPGD | |
| SCHEMBL7006966 | 0.83 | CHRNB4 (0.55) | CHRNB4CHRNA3PRKCZ | |
| SCHEMBL2172629 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3PRKCZHPGD | |
| SCHEMBL5261782 | 0.81 | PRKCZ (0.37) | CHRNB4CHRNA3PRKCZMKNK1 | |
| SCHEMBL11456123 | 0.81 | SLC6A2 (0.53) | SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL6645965 | 0.80 | CHRNB4 (0.44) | CHRNB4CHRNA3PRKCZMKNK1 | |
| SCHEMBL6628961 | 0.80 | CHRNB4 (0.51) | CHRNB4CHRNA3 | |
| SCHEMBL6073607 | 0.80 | CHRNB4 (0.47) | CHRNB4CHRNA3HPGD | |
| SCHEMBL4969157 | 0.79 | PRKCZ (0.36) | CHRNB4CHRNA3PRKCZMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987042-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | sanofi-aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| EP-1987006-A1 | NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Sanofi-Aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093365-A2 | NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007093366-A1 | NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |