Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | RXRB | P28702 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491926 | 0.88 | SMN1; SMN2 (0.59) | PTPN11SMN1; SMN2KDM4ELMNATP53 | |
| SCHEMBL6487707 | 0.87 | SMN1; SMN2 (0.57) | PTPN11SMN1; SMN2KDM4ELMNATP53 | |
| SCHEMBL9697885 | 0.87 | HCRTR1 (0.69) | PTPN11SMN1; SMN2KDM4ELMNATP53 | |
| SCHEMBL6492999 | 0.87 | SMN1; SMN2 (0.57) | PTPN11SMN1; SMN2KDM4ELMNATP53 | |
| SCHEMBL27795075 | 0.86 | PTPN11 (0.60) | PTPN11SMN1; SMN2ALDH1A1FOLH1HSD17B10 | |
| SCHEMBL5348527 | 0.85 | PTPN11 (0.79) | PTPN11SMN1; SMN2TP53TSHR | |
| SCHEMBL28214486 | 0.84 | SMN1; SMN2 (0.54) | PTPN11SMN1; SMN2KDM4ELMNATP53 | |
| SCHEMBL6940402 | 0.84 | PTPN11 (0.81) | PTPN11TP53TSHR | |
| SCHEMBL4599123 | 0.84 | PTPN11 (0.81) | PTPN11TP53TSHR | |
| SCHEMBL7755264 | 0.84 | PTPN11 (0.81) | PTPN11TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |